Your drug development solution provider

Capabilities & Methods

Our GLP-certified laboratory has high-capacity UPLC/MSS/MS equipments. Our state-of-the-art equipment, instrumentation, and software includes the following:

Mass spectrometers

  • Triple Quad 5500TM (AB Sciex)
  • 6495 Triple Quad MS (Agilent)
  • TQD® (Waters)

Liquid chromatography systems

  • 1290 Infinity LC system (Agilent)
  • 1290 Infinity II multisampler (Agilent)
  • CTC PAL autosampler (CTC Analytics)
  • UPLC Acquity® (Waters)

Automated 96-well sample preparation

Validated Analytical softwares (GAMP 5, 21 CFR Part 11 compliant)

  • Analyst 1.6.0 (AB Sciex)
  • Masshunter B.07.00 (Agilent)
  • MassLynx 4.1 (Waters)
  • Dynakin also provides complete services for storing reference products and biological samples. Our facility features:
    • Refrigerated storage (4ºC)
    • Low temperature storage (-20ºC, and -80ºC)
    • Emergency back-up electrical and heating services
    • An uninterrupted Power Supply unit (UPS)
    • On-site archive facility with limited access, environmentally controlled.

CYTOSTATIC DRUGS: VALIDATED BIONALYTICAL METHODS

Compound Analytical method Matrix Sample volume (µl) Range
Bortezomib UPLC/MS/MS Human EDTA Plasma ultrafiltrate 100 1-100 ng/ml
Capecitabine, FBAL, 5-Fu, 5-DFUR UPLC/MS/MS Human EDTA Plasma 50 Capecitabine: 100-10000 ng/ml
FBAL: 200-10000 ng/ml
5-DFUR: 00-10000 ng/ml
5-Fu: 5-1000 ng/ml
Doxorubicin, doxorubicinol UPLC/MS/MS Human EDTA Plasma 100 1-200 ng/ml
Gemcitabine, 2’,2’-Difluoro-2’-deoxyuridine (dFdU) UPLC/MS/MS Human EDTA Plasma 50 Gemcitabine:1-100ng/ml
dFDU: 1000-100000 ng/ml
Olaparib UPLC/MS/MS Human EDTA Plasma 100 5-5000 ng/ml
Paclitaxel UPLC/MS/MS Human EDTA Plasma 100 5-1000 ng/ml
Paclitaxel UPLC/MS/MS Tissues (pig) Biopsies 5-1000 ng/g
Pomalidomide UPLC/MS/MS Human EDTA Plasma 100 0,25-100 ng/ml

OTHER VALIDATED BIONALYTICAL METHODS

Compound Analytical method Matrix Sample volume (µl) Range
Ambroxol UPLC/MS/MS Human EDTA Plasma 100 0.3-50 ng/ml
Cyclosporine A UPLC/MS/MS Whole blood samples (human, pigs) 50 5-1000 ng/ml
Cyclosporine A UPLC/MS/MS Tissues (pig) Biopsies 5-1000 ng/g
Fentanyl UPLC/MS/MS Human EDTA Plasma 100 20-5000 pg/ml
Fentanyl UPLC/MS/MS Dried blood sploot 25 200-50000 pg/ml
Ibuprofen
(R-(-)-ibuprofen; S-(+)-ibuprofen)
UPLC/MS/MS Human EDTA Plasma 100 10-10000 ng/ml
Loperamide UPLC/MS/MS Human EDTA Plasma 100 100-25000 pg/ml
Megestrol UPLC/MS/MS Human EDTA Plasma 100 1-200 ng/ml
Methylphenidate
(d-methylphenidate, l-methylphenidate)
UPLC/MS/MS Human Potassium oxalate with sodium fluoride plasma 100 0.1-20 ng/ml
Monomethyl fumarate UPLC/MS/MS Human Potassium oxalate with sodium fluoride plasma 250 10-2000 ng/ml
Monoethyl fumarate UPLC/MS/MS Human Potassium oxalate with sodium fluoride plasma 250 10-2000 ng/ml
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